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Jobst, K. , and Smith, A. D. (1998). Accuracy of clinical eperational diagnostic criteria for Alzheimer's disease in relation to different pathological diagnostic protocols. Dement. Geriatr. Cogn. Disord. 9, 219-226. , Esiri, M. , and Smith, A. D. (1995). Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neuroscience69, 757-761. , Esiri, M. , Jobst, K. , Morris, J. , King, E. , and Smith, A. D. (1997a). J. Neuropathol.

Prevalence, incidence and duration of Braak's stages in the general population: Can we know? NeurobioL Aging 18, 362-369. Elias, M. , White, R. E, and D'Agosdno, R. B. (2000). The preclinical phase of Alzheimer disease: A 22-year prospective study of the Framingham Cohort. Arch. NeuroL 57, 808-813. ALZHEIMER'S DISEASE 205 Englund, E. (1998). Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dement. Geriatr. Cogn. Disord. 9(suppl 1), 6-12. Farmer, M. , White, L.

Alternative m e c h a n i s m s were also p r o p o s e d for the link between AD and microvascular pathology. , 1999). T h e effect was also d e m o n s t r a t e d when n e u r o n s were cultured with m e d i a conditioned by AD microvessels, suggesting a soluble substance is responsible for the n e u r o d e g e n e r a t i o n . , 1999). , 1997). , 1997). , 1997a). , 1999). Furthermore, it was demonstrated that impaired circulation can result in increased Aft deposition. , 2000), whereas in humans, soluble A/31-42/43 levels are similar in patients with multi-infarct dementia and AD (Kalaria, 2000).

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