By Wojciech Gorczyca
This wide reference overlaying neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors concerning lymph nodes, spleen, bone marrow, and typically affected extranodal organs, with exact emphasis at the differential analysis. It discusses uncomplicated scientific, prognostic, morphologic and phenotypic facts, with quite a few tables summarizing the phenotypic profiles of the most typical hematologic tumors. an enormous function of this booklet is an method of hematologic tumors in response to the WHO type, with correct examples and emphasis at the most beneficial morphologic and immunophenotypic gains utilized in diagnosis.It can be a useful reference for all working towards hematologists, oncologists and pathologists.
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Additional resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
CD43 is useful in differentiating FL (CD43−) from Burkitt lymphoma (CD43+). These two lymphomas differ also in expression of bcl-2. Most FL are bcl-2+ and Burkitt lymphomas are bcl-2−. Bcl-2 is also helpful in differentiating follicular hyperplasia (CD10+ germinal center cells are bcl-2−) from FL (CD10+ cells are most often bcl-2+). Bcl-1 (cyclin D1) is positive in MCL and a subset of HCL and plasma cell myelomas. FL, Burkitt lymphoma and a subset of DLBCL are bcl6 +. 16 Aberrant expression of bcl-6 and CD10 by mantle cell lymphoma (A, histology; B, D, E, immunohistochemistry; C, F, flow cytometry).
Dim expression of TCRαβ, lack of both TCR-associated antigens or positive expression of TCRγδ, on a significant proportion of T-cells indicates a malignant process. Of the additional (non-T-cell-associated) antigens useful in the diagnosis of T-cell lymphoproliferations, the most commonly applied are CD30, CD16, CD56, CD57, CD117 and CD10. CD30 is expressed by anaplastic large cell lymphoma and a subset of other T-cell disorders, including peripheral T-cell lymphoma, and unspecified and enteropathy-type T-cell lymphoma.
5% 30% *All cases of CD117+ tumors were CD8+; X=not evaluated; CD10 expression in angioimmunoblastic lymphoma corresponds to cases in which majority of tumor cells were CD10+. 5%) and lack of CD7 (58% vs 98%) than T-ALL/LBL. The presence of CD1a, CD13, CD33, CD34, and TdT indicates T-ALL/LBL. 10 summarizes FC phenotypic characteristics of different types of acute leukemias. The majority of acute leukemias have blasts with low orthogonal side scatter (SSC), whereas all cases of hypergranular variants of APL are characterized by high SSC (similar to maturing granulocytes).