By Herbert Begemann
-Enhanced sixth version comprises extra illustrations and documented figures
-A excellent reference for hematological and oncological departments and the clincal labortory
-Classified findings from the realm overall healthiness Organization
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Extra resources for Atlas of Clinical Hematology
The myelocyte is the most plentiful granulocytopoietic cell type found in the bone marrow. As maturation progresses the nuclear chromatin becomes even coarser and more clumped. The nucleus becomes indented or horseshoe-shaped, while the cytoplasm and granules remain essentially the same as in mature myelocytes. The cells at this stage are called metamyelocytes or juvenile forms (cells 14-19). A few 48 may be found in the peripheral blood. Metamyelocytes are no longer capable of division. The band neutrophil (cells 20-28) is distinguished from the metamyelocyte by its smaller and coarser nucleus.
Most have the same diameter as the segmented cells, but many are considerably smaller (4-8 Ilm). Usually their cytoplasm is slightly more basophilic than in segmented forms, and their granules are coarser and often smudged. Pronounced nuclear pyknosis is typical, and from three to five solid, structureless nuclear masses may be found scattered like drops in the cytoplasm. There are few if any filaments interconnecting the nuclear remnants. In severe infections and bone marrow injury, it is common to find large purple granules in the myelocytes and in more mature stages up to the segmented forms.
Elliptocytes (ovalocytes). These result from an inherited anomaly of erythrocyte shape which is usually innocent but may be associated with a tendency toward hemolytic anemia (elliptocytic anemia). 7. Macrocytes in the setting of liver disease. The erythrocytes are abnormally large (diam. 8-10 11m) but retain a normal hemoglobin content (MeHC). 8. Basophilic stippling of erythrocytes is a sign of increased but impaired regeneration. It is very commonly seen in lead poisoning. The normal prevalence of basophilic stippling is 0-4 erythrocytes per 10,000.