By Havazelet Bianco-Peled, Maya Davidovich-Pinhas
Bioadhesion is usually outlined because the kingdom within which fabrics, a minimum of certainly one of that's organic in nature, are held jointly for prolonged sessions of time by means of interfacial forces. it really is a space of energetic multidisciplinary learn, the place engineers, scientists―including chemists, physicists, biologists, and clinical experts―materials’ manufacturers, and brands mix their wisdom. From the sensible perspective, bioadhesive platforms were used for a number of years for scientific purposes similar to dentistry and orthopedics and are actually getting into new fields, for instance, tissue sealing and directed drug supply structures. realizing bioadhesion mechanisms is of leading value whereas exploring wanted adhesion for bioadhesion functions corresponding to sealants in addition to profitable prevention of undesired adhesion of biomolecules, cells, or organisms. Controlling the prevalence of bioadhesion occasions is usually a tremendous challenge within the layout and use of scientific units, biosensors, membranes, ships, and oil rigs.
This booklet presents a finished view of bioadhesion and highlights assorted points of this phenomenon. the 1st portion of the publication offers basics features of bioadhesion. It additionally summarizes quite a few direct and oblique tools used to enquire and symbolize bioadhesion. the second one part describes experiences of normal adhesives. those contain "wet" adhesives which are produced and secreted via sessile marine organisms reminiscent of mussels and sand tubes and "dry" adhesives akin to the only characterizing the gecko foot. The 3rd part specializes in biomimetic adhesives. those man-made fabrics are fabricated at the foundation of the teachings realized from nature emphasizing the correlation among nature figuring out and biomimetics. eventually, the final part studies clinical purposes of adhesive fabrics, which come with surgical sealants, mucoadhesive drug supply autos, and prevention of adhesion on clinical devices.
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Extra info for Bioadhesion and biomimetics : from nature to applications
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This Chapter provides an overview of the various in vitro, ex vivo and in vivo techniques that have been extensively used in the characterization of bio-/mucoadhesion drug delivery systems. 1 Introduction The primary aim of a bioadhesive-based drug delivery system is to prolong the residence time at the site of application. Prolonged residence time is advantageous since it will provide effective local drug delivery at the site of application for long-term. Bioadhesivebased drug delivery systems are available in a wide range of pharmaceutical dosage forms such as gels, creams, tablets, patches, and films.