By Marcel Bessis
The translation of Blood Smears Reinterpreted was once started while the French unique used to be nonetheless present process revisions. i used to be accorded the oppor tunity to question any assertion or flip of word that was once uncertain to me or seemed vulnerable to misinterpretation. it really is my desire that hence, ambiguities-particularly these inherent in transformations among American and ecu ropean usage-have been got rid of and i have at the very least ap proached the last word target of any translation: to mirror the author's goal effectively whereas last as readable because the unique. past the function of translator, i used to be inspired to imagine the function of critic. accordingly, a few pages or perhaps unmarried sentences have been hotly debated, occasionally for hours, as Marcel Bessis insisted that any inter pretations on which lets no longer agree could be so indicated. in reality our dialogue consistently led to contract, notwithstanding they ended in alterations of a sentence right here or a note there and, sometimes, to the addition of a footnote or a quick paragraph.
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Extra info for Blood Smears Reinterpreted
Their color IS often almost black violet against a rose background. They may give the nucleus a cartwheel appearance which is quite characteristic of normoblasts. The number of these chromocenters varies from 15 to 20 but IS always above 10, which distinguishes the nuclei of normoblasts from those of plasma cells In which the clumps rarely exceed 9 (see p. 176). The cytoplasm is a uniform blue with very few colorless areas. The centrosome IS seldom recognizable. Mitoses of Normoblasts (E, to E4 ) Mitoses are frequently seen In normal bone marrow aspirates.
And particularly E. are engaged in characteristic movements. Round projections appear suddenly In different parts of the cellular circumference and are as rapidly withdrawn. These movements are probably related to the extrusion of the nucleus (see p. 36). Occasionally they are reflected In smears as distortions in the E. cytoplasmic contour which appears to consist of multiple half-moons (see Fig. 2, p. 37). Electron Microscopy" 2 The nucleus becomes smaller and smaller. The chromatin masses condense and become more sharply separated from the nuclear sap which forms the network extending to the nuclear pores.
With more and more refined techniques one might hope to Identify the first moment at which the initiation of differentiation can be characterized. , a cell that can develop only Into one specific line) Amplification normally takes place concomitantly With maturation. Amplification vanes in different cell lines In the red cell series, one committed cell ordinanly gives rise to 16 fully differentiated cells (see p. 20). Modulation At each stage of maturation, the cell may assume different morphologiC aspects if the environment changes.