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By Obrien

This authoritative reference provides the most recent learn at the function of chemokines, chemokine receptors, and genetic variability within the susceptibility, prevention, and remedy of HIV-1-exploring new healing techniques for more advantageous therapy of HIV-1 contaminated sufferers through blockading chemokine receptor expression. With contributions from pro specialists within the box, Chemokine Receptors and AIDS information ·the function of chemokine receptors in HIV-1 an infection and pathogenesis ·the identity and position of the CCR5-D32 allele in HIV an infection ·potential novel tips on how to deal with HIV-1 an infection via blocking off or down-regulating the CCR5 and CXCR4 HIV-1 coreceptors ·strategies utilizing monoclonal antibodies, small molecules, and ribosymes ·and extra! delivering greater than 1200 present references, Chemokine Receptors and AIDS is a vital reference for infectious affliction experts, epidemiologists, virologists, immunologists, pharmacologists, medicinal chemists and biochemists, microbiologists, and scientific scholars in those disciplines.

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Extra resources for Chemokine Receptors and AIDS (Infectious Disease and Therapy)

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G. E. A. A. Thompson, K. Petraki, and I. Westwick. 1999. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. 1. /nvest. 104: 1061. 81. , BJ. Rutledge, L. Gu, J. W. L. Kunkel, R. North, e. J. Rollins. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein I-deficient mice. 1. Med. 187:601. 82. , G. Warr, I. Loy, and R Bravo. 1997. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor.

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Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog [published erratum appears in Science 1995 Oct 20;270(5235):365]. Science 265:682. 91. , P. Montravers, C. Gibert, C. M. Desmonts, lY. A Gougerot-Pocidalo. 1993. High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. lmmun. 61:4553. 92. L. R. Shah, R. O. D. M. M. Strieter. 1995. Macrophage inflammatory protein-I-beta - a c-c chemokine in osteoarthritis.

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