By Guy B. Faguet
Veterans Affairs scientific middle, Augusta, GA. stories clinical advances in molecular genetics and biology of persistent lymphocytic leukemia. Discusses the scientific facets, concentrating on prognosis, analysis, healing procedures, and issues. additionally addresses familial and juvenile circumstances. DNLM: Leukemia, Lymphocytic, persistent.
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Extra info for Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management
Rai stage IA contains two-thirds of the patients, and Rai stage IB contains one-third of the patients, with 5-yr survivals of 78% and 52%, respectively. Rai stage IIA contains one-third of the patients, and Rai stage IIB contains two-thirds of the patients, with 5-yr survivals of 68% and 38%, respectively. See Figs. 32 and 33 for a comparison of the Rai and Binet systems, and see Fig. 34 for the overall survival of Rai stage IA and IB, Rai stage IIA and IIB, and Rai stage IIIA, IIIB, and IIIC. Of course the Binet system confirms the poor prognostic outcome of the anemic and thrombocytopenic patient (52).
Forty-seven percent, 57%, and 56% of the patients in the three groups, respectively, died. 21). (From ref. , 2000, Fig. 3. Copyright © 2000 Massachusetts Medical Society. ) Both reports concerned patients with non-Hodgkin’s lymphoma and multiple myeloma. The probability of a response in the first study (increase > 2 g Hgb) reached 62% in the group treated with 10,000 IU daily after 8 wk. In the second study a cumulative response frequency of 60% for the fixed dose and variable stepwise dose was seen.
Criel et al. (97) provide two types of survival curves: the effects of typical and atypical morphology (Fig. 35) and the effects of cytogenetics upon typical and atypical morphology (Fig. 36). 4. Molecular Genetics In 1987 and 1989, Shen et al. (99) and Kipps et al. (100) made a major contribution to the molecular analysis of Ig genes in CLL. Their initial observation was that the B-cell antibody repertoire in CLL was limited. This was based on the finding that certain variable (V) region heavy chain (H) Ig genes were expressed more frequently and in fact that certain genes within a given family were expressed at an even higher frequency.