By Harald Klaus Theml, Heinz Diem, Torsten Haferlach
A Flexibook for either the professional and non-specialist, the new booklet bargains obtainable info on hematology in a succinct structure. as well as offering simple technique, the ebook makes use of greater than 260 colour illustrations to aspect the main up to date scientific tactics. various tables and move charts are incorporated to aid in differential prognosis, making this a worthwhile didactic reference for nurses, training physicians and citizens getting ready for board examinations.
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Extra info for Color Atlas of Hematology - Practical and Clinical Diagnosis
54 Normal Cells of the Blood and Hematopoietic Organs Distribution and Cell Quality in Erythropoiesis. In erythropoiesis polychromatic erythroblasts normally predominate. Proerythroblasts and basophilic erythroblasts only make up a small portion (Table 4). Here, too, a left shift indicates an increase in immature cell types and a right shift an increase in orthochromatic erythroblasts. Qualitatively, vitamin B12 and folic acid deficiency lead to a typical loosening-up of the nuclear structure in proerythroblasts and to nuclear segmentation and break-up in the erythroblasts (megaloblastic erythropoiesis).
A spontaneous decrease in lymphocyte counts is normally seen only in very rare congenital diseases (agammaglobulinemia [Bruton disease], DiGeorge disease [chromosome 22q11 deletion syndrome]). Some systemic diseases also lead to low lymphocyte counts (Hodgkin disease, active AIDS). Mature plasma cells are rarely found in blood (plasma cell leukemia is extremely rare). Plasma-cell-like (“plasmacytoid”) lymphocytes occur in viral infections or systemic diseases (see p. 68 f. and p. ). Lymphocytes are small round cells with dense nuclei and some variation in their appearance a b c d e f g Fig.
45 46 Normal Cells of the Blood and Hematopoietic Organs Monocytes Monocytes are produced in the bone marrow; their line of development branches off at a very early stage from that of the granulocytic series (see flow chart p. 3), but does not contain any distinct, specific precursors that can be securely identified with diagnostic significance in everyday morphological studies. Owing to their great motility and adhesiveness, mature monocytes are morphologically probably the most diversified of all cells.