By Gretchen M. Lentz, Roger A. Lobo, David M. Gershenson, Vern L. Katz
Accomplished Gynecology provide you with entire, well timed, and straightforward entry to very important details on the entire scientific and surgical concerns affecting your perform. even if you're a resident or practioner, you'll get the entire functional, in-depth assurance you want to remain on the vanguard of your box. Now in its 6th version, this center reference, previously edited through Drs. Droegemueller, Stenchever, Mishell and Herbst, remains to be your fundamental source for in-depth and up to date information.
stay awake thus far with the newest gynecologic advances via transparent writing, a medical concentration, and a spotlight on evidence-based practices.
organize for the demanding situations you'll face in perform with a very overhauled criminal bankruptcy containing actual scenarios.
seek the total textual content on-line at www.expertconsult.com.
remain present on your box with the latest advances in breast care; endoscopy and hysteroscopy; menopausal bone health and wellbeing; criminal concerns affecting our perform; and lots more and plenty more.
entry cutting-edge counsel at the most recent functions in diagnostic and interventional ultrasound - and plenty of different crucial points of today's perform - via particular sections at the molecular biology of particular gynecologic malignancies and a brand new bankruptcy on Fallopian Tube and first Peritoneal Cancer.
realize the interactions and affects of woman body structure on significant affliction techniques with a brand new bankruptcy at the interplay of scientific illnesses and feminine Physiology.
deal with each patient's wishes with the Emotional concerns in Gynecology bankruptcy, now changed in partnership with a psychiatrist, and up-to-date details on depression/anxiety treatment.
Comprehensive Gynecology is the must-read textual content for either citizens and tested practitioners.
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Additional resources for Comprehensive Gynecology (6th Edition)
CGH is used to measure differences in copy number or dosage of a particular chromosome segment. Its widest application has been in the study of gene dosage in normal and cancer cell lines. Currently, aCGH has replaced conventional cytogenetics as the first-line test of an individual with unexplained birth defects or mental retardation. The second technique, SKY, uses the FISH principle to visualize all 24 chromosomes by “painting” with chromosome-specific probes in different colors simultaneously.
More interestingly, 30% of subjects with PWS do not have a cytogenetic deletion but rather inherit two intact chromosomes 15 from the mother. No genetic information on chromosome 15 is inherited from the father. This is referred to as maternal uniparental disomy. As expected, individuals with Angelman syndrome without a cytogenetic deletion have two copies of the paternally derived chromosome 15 and no chromosome 15 from the mother—a condition termed paternal uniparental disomy. These findings indicate that at least for the region of 15q11-q13, the expression of the PWS phenotype is brought on by the absence of a paternal contribution of the genes in this region.
Depending on the ethnic group of the mother and father, the risk for a child having Figure 2-14 Pedigree illustrating autosomal recessive inheritance. Here the parents of the affected children are first cousins, as denoted by the double line connecting them. ) 2 Table 2-2 Carrier Frequencies for Cystic Fibrosis in Different Populations Ethnicity Chance of Being Carrier Chance Both Carriers* European descent Hispanic American African American Asian American 1 1 1 1 1 in 1 in 1 in 1 in in 29 in 46 in 65 in 90 841 2,116 4,225 8,100 *The chance for an affected child being born to these couples is the chance that both are carriers times ¼.